Human Procollagen Type I N-Terminal Propeptide (PINP) CLIA Kit
845€ (96 tests)
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935106861
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name
Human Procollagen Type I N-Terminal Propeptide (PINP) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx492263
tested applications
CLIA
Description
Human Procollagen I N-Terminal Propeptide (PINP) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Procollagen Type I N-Terminal Propeptide (PINP) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.27 ng/ml - 200 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | PINP,P1NP |
| Background | CLIA Kits PINP |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Procollagen Type I N-Terminal Propeptide (PINP) is a cleavage product released during the biosynthesis of type I collagen, which is the most abundant collagen type found in bones, skin, and connective tissues. It serves as a sensitive and specific biomarker for bone formation, reflecting the activity of osteoblasts and the overall rate of collagen synthesis. PINP is widely used in clinical and research settings to monitor bone metabolism, particularly in conditions such as osteoporosis, Paget's disease, and metabolic bone disorders. It is often measured to assess the effectiveness of anabolic or anti-resorptive treatments in improving bone health. PINP levels can also indicate increased collagen turnover in fibrotic diseases, including liver fibrosis and systemic sclerosis, where excessive extracellular matrix production occurs. PINP exists in two forms in circulation, the intact trimer and a smaller monomer, both of which are measurable through immunoassays. The protein's dynamic association with bone remodeling and extracellular matrix synthesis underscores its importance as a marker for tissue repair and fibrotic activity. Emerging research highlights its potential in oncology, where altered PINP levels are linked to metastatic bone disease and tumor-induced bone resorption.
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