Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Protein

234€ (10 µg)
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935106861
info@markelab.com
name
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166810
tested applications
WB, SDS-PAGE
Description
Arachidonate-15-Lipoxygenase, Type B Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 30.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg253-Glu490 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 95% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | O15296 |
Alias | 15-lipoxygenase 2,Arachidonate 15-lipoxygenase B |
Background | Protein ALOX15B |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALOX15B, a close homolog of ALOX15, catalyzes the formation of 15(S)-HETE from arachidonic acid and other polyunsaturated fatty acids. Unlike ALOX15, ALOX15B is highly expressed in epithelial tissues, including the prostate, lung, and skin, where it plays a role in maintaining cellular homeostasis, inflammation resolution, and lipid metabolism. ALOX15B-derived lipid mediators regulate anti-inflammatory responses and oxidative stress, contributing to tissue repair and barrier function. Its dysregulation has been implicated in prostate cancer, where altered ALOX15B expression promotes cell proliferation, survival, and tumor progression through lipid signaling pathways. In addition, ALOX15B has a role in metabolic diseases, such as obesity and diabetes, where it influences lipid signaling and insulin sensitivity. ALOX15B’s ability to modulate inflammatory pathways and lipid homeostasis makes it a potential therapeutic target for cancer, metabolic disorders, and inflammatory diseases.
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