Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) ELISA Kit
689€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx150619
tested applications
ELISA
Description
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) concentrations in serum, plasma, tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Arachidonate-15-Lipoxygenase, Type B (ALOX15B)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | 15-lipoxygenase 2,Arachidonate 15-lipoxygenase B |
| Background | Elisa kits for ALOX15B |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALOX15B, a close homolog of ALOX15, catalyzes the formation of 15(S)-HETE from arachidonic acid and other polyunsaturated fatty acids. Unlike ALOX15, ALOX15B is highly expressed in epithelial tissues, including the prostate, lung, and skin, where it plays a role in maintaining cellular homeostasis, inflammation resolution, and lipid metabolism. ALOX15B-derived lipid mediators regulate anti-inflammatory responses and oxidative stress, contributing to tissue repair and barrier function. Its dysregulation has been implicated in prostate cancer, where altered ALOX15B expression promotes cell proliferation, survival, and tumor progression through lipid signaling pathways. In addition, ALOX15B has a role in metabolic diseases, such as obesity and diabetes, where it influences lipid signaling and insulin sensitivity. ALOX15B’s ability to modulate inflammatory pathways and lipid homeostasis makes it a potential therapeutic target for cancer, metabolic disorders, and inflammatory diseases.
Related Products
Human ALOX15B (Arachidonate 15-lipoxygenase B) ELISA Kit
Ver Producto
Rat ALOX15B (Polyunsaturated fatty acid lipoxygenase ALOX15B) ELISA Kit
Ver Producto
ALOX15B antibody
In humans, there are 6 functional lipoxygenases genes. Two of them encode for arachidonic acid 12-lipoxygenating(ALOX12, ALOX12B) and two for 15-lipoxygenating enzymes(ALOX15, ALOX15B). ALOX15B has been described as the most abundant 15-lipoxygenating enzyme species in human carotid atherosclerotic lesions and to be associated with cerebrovascular symptoms.(PMID:24373925). ALOX15B has 4 isoforms produced by alternative splicing with the MW of 76, 67, 69 and 73 kDa.
Ver Producto