Human Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Protein

247€ (10 µg)
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name
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167149
tested applications
WB, SDS-PAGE
Description
Arachidonate-12-Lipoxygenase Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 38.3 kDa Observed MW (SDS-PAGE): 38 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe352-Cys656 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | ALOX12,12LO,LOG12 |
Background | Protein ALOX12 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALOX12 is a member of the lipoxygenase enzyme family that catalyzes the oxygenation of arachidonic acid to produce 12(S)-hydroperoxyeicosatetraenoic acid [12(S)-HPETE], which is further reduced to 12(S)-HETE. This reaction is critical for the biosynthesis of lipid mediators involved in inflammation, platelet aggregation, and cellular signaling. ALOX12 is highly expressed in platelets and plays a significant role in hemostasis and thrombosis by modulating platelet activation and aggregation. In addition to its role in normal physiological processes, dysregulation of ALOX12 is associated with inflammation, atherosclerosis, and cancer progression. ALOX12-derived lipid mediators contribute to tumor microenvironment remodeling, promoting cell proliferation, migration, and angiogenesis. In neurodegenerative diseases, ALOX12 activity has been implicated in oxidative stress and neuronal injury, particularly in conditions like Parkinson's disease. Its role in inflammatory and oxidative processes makes ALOX12 a promising therapeutic target for cardiovascular, cancer, and neuroinflammatory diseases.
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