Human Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein ALOX12
proveedor
Abbexareference
abx167149Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Arachidonate-12-Lipoxygenase Protein is a recombinant Human protein expressed in E. coli.
Background
ALOX12 is a member of the lipoxygenase enzyme family that catalyzes the oxygenation of arachidonic acid to produce 12(S)-hydroperoxyeicosatetraenoic acid [12(S)-HPETE], which is further reduced to 12(S)-HETE. This reaction is critical for the biosynthesis of lipid mediators involved in inflammation, platelet aggregation, and cellular signaling. ALOX12 is highly expressed in platelets and plays a significant role in hemostasis and thrombosis by modulating platelet activation and aggregation. In addition to its role in normal physiological processes, dysregulation of ALOX12 is associated with inflammation, atherosclerosis, and cancer progression. ALOX12-derived lipid mediators contribute to tumor microenvironment remodeling, promoting cell proliferation, migration, and angiogenesis. In neurodegenerative diseases, ALOX12 activity has been implicated in oxidative stress and neuronal injury, particularly in conditions like Parkinson's disease. Its role in inflammatory and oxidative processes makes ALOX12 a promising therapeutic target for cardiovascular, cancer, and neuroinflammatory diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 38.3 kDa Observed MW (SDS-PAGE): 38 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe352-Cys656 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ALOX12
dry ice
No
availability
Shipped within 5-7 working days.
alias
ALOX12,12LO,LOG12
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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