Human Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) CLIA Kit

Este producto es parte de ALOX - Arachidonate lipoxygenase
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Human Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195083
tested applications
CLIA

Description

Human Arachidonate 12-Lipoxygenase (12-LO) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Arachidonate 12-Lipoxygenase (12-LO).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
62.5 pg/ml - 4000 pg/ml
Sensitivity
37.5 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
ALOX12,12LO,LOG12
Background
CLIA Kits ALOX12
Status
RUO
Note
The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ALOX12 is a member of the lipoxygenase enzyme family that catalyzes the oxygenation of arachidonic acid to produce 12(S)-hydroperoxyeicosatetraenoic acid [12(S)-HPETE], which is further reduced to 12(S)-HETE. This reaction is critical for the biosynthesis of lipid mediators involved in inflammation, platelet aggregation, and cellular signaling. ALOX12 is highly expressed in platelets and plays a significant role in hemostasis and thrombosis by modulating platelet activation and aggregation. In addition to its role in normal physiological processes, dysregulation of ALOX12 is associated with inflammation, atherosclerosis, and cancer progression. ALOX12-derived lipid mediators contribute to tumor microenvironment remodeling, promoting cell proliferation, migration, and angiogenesis. In neurodegenerative diseases, ALOX12 activity has been implicated in oxidative stress and neuronal injury, particularly in conditions like Parkinson's disease. Its role in inflammatory and oxidative processes makes ALOX12 a promising therapeutic target for cardiovascular, cancer, and neuroinflammatory diseases.

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