Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) CLIA Kit

Este producto es parte de ADCYAP1 - adenylate cyclase activating polypeptide 1 ( RECEPTOR)
Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) CLIA Kit
845€ (96 tests)

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Name
Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) CLIA Kit
Category
CLIA Kits
Provider
Abbexa
Reference
abx490410
Tested Applications
CLIA

Description

Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Chemiluminescent Immunoassay (CLIA) Kit is a Competitive Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
CLIA Kits
Immunogen Target
Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Competitive
Test Range
6.17 pg/ml - 500 pg/ml
Sensitivity
< 2.55 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard: Lyophilized
Tested Applications
CLIA
Sample Type
Serum, plasma, tissue homogenates and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P18509
Gene ID
116
OMIM
102980
Alias
PACAP
Background
CLIA Kits ADCYAP1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.  Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Adenylate Cyclase Activating Polypeptide 1 (ADCYAP1) is a neuropeptide that acts as a ligand for its receptor, ADCYAP1 receptor. It plays crucial roles in regulating various physiological processes, including neurotransmission, neuroprotection, and modulation of the stress response. The ADCYAP1 receptor, also known as PAC1 receptor, is widely distributed throughout the central nervous system and peripheral tissues, indicating its diverse functions. Upon binding of ADCYAP1 to its receptor, intracellular signaling pathways are activated, leading to the production of cyclic adenosine monophosphate (cAMP) and subsequent activation of protein kinase A (PKA) and other downstream effectors. This signaling cascade influences synaptic transmission, neuronal excitability, and cellular responses to stressors. Dysregulation of ADCYAP1 signaling has been implicated in various neurological and psychiatric disorders, including anxiety, depression, and neurodegenerative diseases. Understanding the mechanisms underlying ADCYAP1 receptor activation provides insights into its physiological functions and potential therapeutic targets for neurological and psychiatric disorders. Ongoing research aims to elucidate the roles of ADCYAP1 signaling in health and disease, paving the way for the development of novel treatment strategies.

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