Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Antibody
273€ (100 µl)
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935106861
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name
Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104654
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O70176 |
| Gene ID | 11516 |
| Alias | PACAP |
| Background | Antibody anti-ADCYAP1 |
| Status | RUO |
Descripción
Adenylate Cyclase Activating Polypeptide 1 (ADCYAP1) is a neuropeptide that acts as a ligand for its receptor, ADCYAP1 receptor. It plays crucial roles in regulating various physiological processes, including neurotransmission, neuroprotection, and modulation of the stress response. The ADCYAP1 receptor, also known as PAC1 receptor, is widely distributed throughout the central nervous system and peripheral tissues, indicating its diverse functions. Upon binding of ADCYAP1 to its receptor, intracellular signaling pathways are activated, leading to the production of cyclic adenosine monophosphate (cAMP) and subsequent activation of protein kinase A (PKA) and other downstream effectors. This signaling cascade influences synaptic transmission, neuronal excitability, and cellular responses to stressors. Dysregulation of ADCYAP1 signaling has been implicated in various neurological and psychiatric disorders, including anxiety, depression, and neurodegenerative diseases. Understanding the mechanisms underlying ADCYAP1 receptor activation provides insights into its physiological functions and potential therapeutic targets for neurological and psychiatric disorders. Ongoing research aims to elucidate the roles of ADCYAP1 signaling in health and disease, paving the way for the development of novel treatment strategies.
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