Human PHF6(PHD finger protein 6) ELISA Kit

Product specifications

ELISA Kits

human

Colorimetric

Quantitative

Sandwich ELISA, Double Antibody

15.625-1000pg/ml

96T

Busacar en las instrucciones

Shipped within 10-14 working days.

2-8 °C for 6 months

Q8IWS0

PHF6,CENP-31,KIAA1823,PHD-like zinc finger protein

Elisa Kits PHF6

RUO

PHF6 is a PHD finger domain-containing protein that functions in transcriptional regulation, chromatin remodeling, and cell cycle control. It interacts with components of chromatin-modifying complexes to facilitate gene silencing or activation, depending on cellular context. PHF6 is expressed in neural and hematopoietic tissues, where it regulates processes such as neurodevelopment, cell proliferation, and differentiation. Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome, a neurodevelopmental disorder characterized by intellectual disability, epilepsy, and craniofacial abnormalities. PHF6 is also implicated in hematological cancers, including T-cell leukemia, where its loss of function disrupts chromatin organization and transcriptional regulation. Knockout studies demonstrate defects in neuronal development, impaired cell cycle progression, and increased genomic instability, highlighting its essential role in chromatin regulation, neurodevelopment, and disease pathogenesis.

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