Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit

Este producto es parte de PPARGC1A -  PPARG coactivator 1 alpha
Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit
715€ (96 tests)

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Name
Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx152808
Tested Applications
ELISA

Description

Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARGC1A)

Documentos del producto

Instrucciones
Descargar
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9UBK2
Gene ID
10891
OMIM
604517
Alias
LEM6,PGC1,PGC1A,PGC-1v,PPARGC1,PGC-1alpha,PGC-1(alpha)
Background
Elisa Kits for: PPARGC1A
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

PPARGC1A, also known as PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), is a transcriptional coactivator that plays a central role in the regulation of cellular energy metabolism and mitochondrial biogenesis. PPARGC1A interacts with and coactivates various transcription factors, including peroxisome proliferator-activated receptor gamma (PPARG) and nuclear respiratory factors (NRFs), to regulate the expression of genes involved in energy metabolism, oxidative phosphorylation, and mitochondrial function. It promotes the transcription of genes involved in fatty acid oxidation, glucose metabolism, and thermogenesis, thereby enhancing cellular energy production and expenditure. PPARGC1A is a master regulator of mitochondrial biogenesis, the process by which new mitochondria are formed. It stimulates the expression of nuclear-encoded mitochondrial genes and activates signaling pathways involved in mitochondrial biogenesis, such as the PPAR signaling pathway and the AMP-activated protein kinase (AMPK) pathway. Increased PPARGC1A activity leads to the proliferation and remodeling of mitochondria, resulting in enhanced cellular energy capacity and metabolic efficiency.

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