Human Paxillin (Pax) Protein
234€ (10 µg)
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935106861
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name
Human Paxillin (Pax) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168179
tested applications
WB, SDS-PAGE
Description
Paxillin Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Paxillin (Pax) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 32.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys201-Lys461 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49023 |
| Alias | PAX,testicular Tissue Protein Li 134 |
| Background | Protein PXN |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Paxillin (PXN) is a focal adhesion-associated adaptor protein that regulates cell adhesion, migration, and cytoskeletal organization by interacting with integrins, growth factor receptors, and signaling proteins at focal adhesions. It contains LIM domains and LD motifs, enabling it to recruit structural and signaling molecules such as focal adhesion kinase (FAK), vinculin, and Src kinases, coordinating actin cytoskeletal dynamics and mechanotransduction. Paxillin is critical for integrin-mediated signaling pathways, linking extracellular matrix (ECM) cues to intracellular processes like cell movement, proliferation, and survival. It plays a key role in embryonic development, tissue remodeling, and wound healing by modulating focal adhesion turnover and actomyosin contractility. Dysregulation of paxillin promotes cancer progression, metastasis, and drug resistance by enhancing cell migration, invasion, and survival signaling. Knockout studies reveal defects in focal adhesion formation, impaired cell motility, and developmental abnormalities, highlighting its essential role in cell adhesion, cytoskeletal regulation, and mechanotransduction.
