Human Parathyroid Hormone (PTH1R) Protein

Este producto es parte de PTHR - Parathyroid Hormone Receptor
Human Parathyroid Hormone (PTH1R) Protein
273€ (10 µg)

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935106861
info@markelab.com
Name
Human Parathyroid Hormone (PTH1R) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx690481
Tested Applications
SDS-PAGE

Description

Parathyroid Hormone (PTH1R) protein is a recombinant Human protein expressed in HEK293 cells.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category 
Proteins and Peptides
Immunogen Target 
Parathyroid Hormone (PTH1R)
Host 
HEK293 cells
Assay Type 
Activity: Not tested
Sequence Fragment: Tyr23-Met189
Tag: C-terminal 6 His tag
Origin 
Human
Observed MW 
Calculated MW: 20.3 kDa  Observed MW (SDS-PAGE): 25-35 kDa
Expression 
Recombinant
Purity 
> 95% (SDS-PAGE)
Purification 
0.2 µm filtered prior to lyophilization.
Size 1 
10 µg
Size 2 
50 µg
Form 
Lyophilized
Tested Applications 
SDS-PAGE
Buffer 
Prior to lyophilization: PBS, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80.
Availability 
Shipped within 5-15 working days.
Storage 
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice 
No
UniProt ID 
Q03431
Gene ID 
5745
OMIM 
125350, 156400, 168468, 215045, 600002
Alias 
PTH1R,PPR,PTHR,PTHR1,EKNS, PFE
Background 
Protein PTH1R
Status 
RUO
Note 
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Background

PTH1R is a G protein-coupled receptor activated by parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It is primarily expressed in bone, kidney, and cartilage, where it regulates calcium and phosphate homeostasis, bone remodeling, and cartilage development. PTH1R couples to both Gs and Gq proteins, leading to activation of adenylate cyclase (increasing cAMP) and phospholipase C (PLC) pathways. In bone, PTH1R mediates osteoblast activation, enhancing bone formation and resorption in response to PTH. In the kidney, PTH1R regulates calcium reabsorption and phosphate excretion to maintain calcium balance. Dysregulation of PTH1R signaling is associated with hyperparathyroidism, hypoparathyroidism, and bone diseases like osteoporosis. PTH analogs that target PTH1R are used therapeutically to treat osteoporosis and hypoparathyroidism by promoting bone growth and mineral homeostasis. PTH1R’s essential role in calcium regulation and skeletal health makes it a key target for metabolic bone diseases.

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