Human Par-3 Partitioning Defective 3 Homolog (PARD3) ELISA Kit

Este producto es parte de PARD3 - Partitioning Defective 3 Homolog
Human Par-3 Partitioning Defective 3 Homolog (PARD3) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PARD3

proveedor

Abbexa

reference

abx382053

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Par-3 Partitioning Defective 3 Homolog (PARD3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PARD3 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PARD3 is a polarity protein essential for establishing and maintaining cell polarity during processes like epithelial tissue organization, asymmetric cell division, and neuronal development. It is a component of the Par complex, which includes PARD6 and atypical protein kinase C (aPKC), and regulates apical-basal polarity by interacting with tight junction components and cytoskeletal regulators. PARD3 is critical for tight junction formation, cell adhesion, and actin cytoskeleton organization in epithelial and endothelial cells. It is highly expressed in polarized tissues and neurons, where it regulates axon specification, neuronal migration, and synaptic organization. Dysregulation of PARD3 contributes to cancer progression, particularly in epithelial tumors, by disrupting cell polarity, adhesion, and promoting metastasis. PARD3 also plays roles in stem cell self-renewal, tissue homeostasis, and endothelial barrier function. Knockout studies reveal defects in tissue architecture, impaired cell polarization, and embryonic lethality, emphasizing its fundamental role in polarity establishment and tissue integrity.

Características del producto

category

ELISA Kits


immunogen target

Par-3 Partitioning Defective 3 Homolog (PARD3)


reactivity

Human


test range

0.313 ng/ml - 20 ng/ml


sensitivity

< 0.188 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PARD3


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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