Human Par-3 Partitioning Defective 3 Homolog (PARD3) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for PARD3
proveedor
Abbexareference
abx382053Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Par-3 Partitioning Defective 3 Homolog (PARD3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PARD3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PARD3 is a polarity protein essential for establishing and maintaining cell polarity during processes like epithelial tissue organization, asymmetric cell division, and neuronal development. It is a component of the Par complex, which includes PARD6 and atypical protein kinase C (aPKC), and regulates apical-basal polarity by interacting with tight junction components and cytoskeletal regulators. PARD3 is critical for tight junction formation, cell adhesion, and actin cytoskeleton organization in epithelial and endothelial cells. It is highly expressed in polarized tissues and neurons, where it regulates axon specification, neuronal migration, and synaptic organization. Dysregulation of PARD3 contributes to cancer progression, particularly in epithelial tumors, by disrupting cell polarity, adhesion, and promoting metastasis. PARD3 also plays roles in stem cell self-renewal, tissue homeostasis, and endothelial barrier function. Knockout studies reveal defects in tissue architecture, impaired cell polarization, and embryonic lethality, emphasizing its fundamental role in polarity establishment and tissue integrity.
Características del producto
category
ELISA Kits
immunogen target
Par-3 Partitioning Defective 3 Homolog (PARD3)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
PARD3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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