Human Paired Box Protein Pax-6 (PAX6) ELISA Kit

Este producto es parte de PAX - Paired box protein Pax
Human Paired Box Protein Pax-6 (PAX6) ELISA Kit
715€ (96 tests)

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Name
Human Paired Box Protein Pax-6 (PAX6) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx382072
Tested Applications
ELISA

Description

Human Paired Box Protein Pax-6 (PAX6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX6 concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Paired Box Protein Pax-6 (PAX6)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.13 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P26367
Gene ID
5080
OMIM
106210
Alias
AN,AN1,AN2,ASGD5,D11S812E,FVH1,MGDA,WAGR,Aniridia type II protein,Oculorhombin
Background
Elisa Kits for: PAX6
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

PAX6 is a highly conserved transcription factor critical for the development of the eyes, central nervous system, and endocrine pancreas. It regulates the expression of genes involved in eye morphogenesis, lens formation, and neuronal differentiation. PAX6 acts as a master regulator of ocular development, with its mutations causing congenital eye disorders such as aniridia, Peters anomaly, and microphthalmia. It also plays a role in brain patterning, where it contributes to neurogenesis and cortical layer formation. PAX6 is essential for pancreatic β-cell development, where it influences insulin production and glucose regulation. Dysregulation of PAX6 has been linked to neurological disorders and metabolic dysfunction. Knockout studies in mice reveal severe ocular malformations, brain developmental defects, and pancreatic abnormalities, highlighting its critical role in tissue differentiation, organogenesis, and cell fate determination during embryonic development.

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