Human Paired Box Protein Pax-6 (PAX6) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Paired Box Protein Pax-6 (PAX6) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx382072
tested applications
ELISA
Description
Human Paired Box Protein Pax-6 (PAX6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX6 concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Paired Box Protein Pax-6 (PAX6) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.13 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P26367 |
| Gene ID | 5080 |
| OMIM | 106210 |
| Alias | AN,AN1,AN2,ASGD5,D11S812E,FVH1,MGDA,WAGR,Aniridia type II protein,Oculorhombin |
| Background | Elisa kits for PAX6 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PAX6 is a highly conserved transcription factor critical for the development of the eyes, central nervous system, and endocrine pancreas. It regulates the expression of genes involved in eye morphogenesis, lens formation, and neuronal differentiation. PAX6 acts as a master regulator of ocular development, with its mutations causing congenital eye disorders such as aniridia, Peters anomaly, and microphthalmia. It also plays a role in brain patterning, where it contributes to neurogenesis and cortical layer formation. PAX6 is essential for pancreatic β-cell development, where it influences insulin production and glucose regulation. Dysregulation of PAX6 has been linked to neurological disorders and metabolic dysfunction. Knockout studies in mice reveal severe ocular malformations, brain developmental defects, and pancreatic abnormalities, highlighting its critical role in tissue differentiation, organogenesis, and cell fate determination during embryonic development.
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