Human Paired Box Protein Pax-3 (PAX3) ELISA Kit

Este producto es parte de PAX - Paired box protein Pax
Human Paired Box Protein Pax-3 (PAX3) ELISA Kit
715€ (96 tests)

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Name
Human Paired Box Protein Pax-3 (PAX3) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx382070
Tested Applications
ELISA

Description

Human Paired Box Protein Pax-3 (PAX3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human PAX3 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Paired Box Protein Pax-3 (PAX3)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.313 ng/ml - 20 ng/ml
Sensitivity
< 0.188 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P23760
Gene ID
5077
OMIM
122880
Alias
CDHS,HUP2,PAX-3,WS1,WS3
Background
Elisa Kits for: PAX3
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

PAX3 is a transcription factor belonging to the paired box (PAX) family, essential for embryonic development, particularly in neural crest cell migration, muscle formation, and melanocyte differentiation. PAX3 regulates genes involved in cell survival, proliferation, and lineage determination during development of the neural tube, skeletal muscles, and craniofacial structures. Mutations in PAX3 are associated with Waardenburg syndrome types I and III, characterized by hearing loss, pigmentation abnormalities, and skeletal defects due to impaired neural crest development. PAX3 also plays a role in myogenesis by activating MyoD and other myogenic regulatory factors. In cancers like alveolar rhabdomyosarcoma, chromosomal translocations involving PAX3 result in oncogenic fusion proteins (e.g., PAX3-FOXO1) that drive tumorigenesis by promoting unchecked proliferation and inhibiting differentiation. Knockout models show defects in neural crest migration, craniofacial anomalies, and muscle development failures, emphasizing PAX3's role in embryonic tissue patterning and organogenesis.

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