Human P2Y Purinoceptor 4 (P2RY4) ELISA Kit

Este producto es parte de P2RY  - Purinergic Receptor P2Y
Human P2Y Purinoceptor 4 (P2RY4) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for P2RY4

proveedor

Abbexa

reference

abx537460

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human P2Y purinoceptor 4 (P2RY4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human P2Y purinoceptor 4 (P2RY4) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

P2RY4 is a G protein-coupled receptor activated by extracellular UTP and ATP. It predominantly couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium levels, leading to activation of downstream signaling pathways. P2RY4 is expressed in epithelial tissues, including the gastrointestinal tract, kidney, and respiratory tract, where it regulates ion transport, fluid secretion, and epithelial cell function. In the intestine, P2RY4 plays a role in chloride and fluid secretion, contributing to mucosal hydration and barrier function. It is also involved in inflammation and tissue repair, particularly in response to extracellular nucleotides released during tissue damage. Dysregulation of P2RY4 signaling has been linked to gastrointestinal disorders, cystic fibrosis, and epithelial dysfunction. Targeting P2RY4 with selective modulators holds therapeutic potential for treating intestinal inflammation, respiratory diseases, and conditions involving impaired ion transport and mucosal hydration.

Características del producto

category

ELISA Kits


immunogen target

P2Y Purinoceptor 4 (P2RY4)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

P2RY4,pyrimidinoceptor,uridine nucleotide receptor,NRU,UNR,P2Y ATP receptor 4,P2Y purinoceptor 4,pyrimidinergic receptor P2Y,NRU,P2P,UNR,P2Y4


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

P2RY4


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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