Human P2Y Purinoceptor 4 (P2RY4) ELISA Kit
715€ (96 tests)
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935106861
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name
Human P2Y Purinoceptor 4 (P2RY4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx537460
tested applications
ELISA
Description
Human P2Y purinoceptor 4 (P2RY4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human P2Y purinoceptor 4 (P2RY4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | P2Y Purinoceptor 4 (P2RY4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P51582 |
| Gene ID | 5030 |
| OMIM | 300038 |
| Alias | P2RY4,pyrimidinoceptor,uridine nucleotide receptor,NRU,UNR,P2Y ATP receptor 4,P2Y purinoceptor 4,pyrimidinergic receptor P2Y,NRU,P2P,UNR,P2Y4 |
| Background | Elisa kits for P2RY4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
P2RY4 is a G protein-coupled receptor activated by extracellular UTP and ATP. It predominantly couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium levels, leading to activation of downstream signaling pathways. P2RY4 is expressed in epithelial tissues, including the gastrointestinal tract, kidney, and respiratory tract, where it regulates ion transport, fluid secretion, and epithelial cell function. In the intestine, P2RY4 plays a role in chloride and fluid secretion, contributing to mucosal hydration and barrier function. It is also involved in inflammation and tissue repair, particularly in response to extracellular nucleotides released during tissue damage. Dysregulation of P2RY4 signaling has been linked to gastrointestinal disorders, cystic fibrosis, and epithelial dysfunction. Targeting P2RY4 with selective modulators holds therapeutic potential for treating intestinal inflammation, respiratory diseases, and conditions involving impaired ion transport and mucosal hydration.
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