Human P2Y Purinoceptor 11 (P2RY11) ELISA Kit

Este producto es parte de P2RY  - Purinergic Receptor P2Y
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715€ (96 tests)

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935106861
info@markelab.com
name
Human P2Y Purinoceptor 11 (P2RY11) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx537470
tested applications
ELISA

Description

Human P2Y purinoceptor 11 (P2RY11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human P2Y purinoceptor 11 (P2RY11) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
P2Y Purinoceptor 11 (P2RY11)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q96G91
OMIM
602697
Alias
P2RY11,purinergic receptor P2Y,G-protein coupled 11,P2Y purinoreceptor 11,P2Y1
Background
Elisa Kits for: P2RY11
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

P2RY11 is a G protein-coupled receptor activated by extracellular ATP and adenosine diphosphate (ADP). Unlike other P2Y receptors, P2RY11 couples to both Gs and Gq proteins, allowing it to stimulate adenylate cyclase and phospholipase C (PLC), increasing cAMP and calcium levels, respectively. P2RY11 is widely expressed in immune cells, including leukocytes, as well as in the heart and central nervous system, where it modulates inflammation, immune responses, and energy metabolism. P2RY11 regulates chemotaxis, immune cell activation, and cytokine secretion, playing an essential role in inflammatory and immune-mediated diseases. It also contributes to cellular energy balance through its regulation of cAMP. Dysregulation of P2RY11 has been linked to autoimmune disorders, cardiac dysfunction, and inflammatory conditions. Targeting P2RY11 has potential therapeutic implications in immune modulation, cardiovascular diseases, and conditions associated with ATP-mediated inflammation.

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