Human P2Y Purinoceptor 11 (P2RY11) ELISA Kit
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Description
Human P2Y purinoceptor 11 (P2RY11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human P2Y purinoceptor 11 (P2RY11) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | P2Y Purinoceptor 11 (P2RY11) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96G91 |
| OMIM | 602697 |
| Alias | P2RY11,purinergic receptor P2Y,G-protein coupled 11,P2Y purinoreceptor 11,P2Y1 |
| Background | Elisa kits for P2RY11 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
P2RY11 is a G protein-coupled receptor activated by extracellular ATP and adenosine diphosphate (ADP). Unlike other P2Y receptors, P2RY11 couples to both Gs and Gq proteins, allowing it to stimulate adenylate cyclase and phospholipase C (PLC), increasing cAMP and calcium levels, respectively. P2RY11 is widely expressed in immune cells, including leukocytes, as well as in the heart and central nervous system, where it modulates inflammation, immune responses, and energy metabolism. P2RY11 regulates chemotaxis, immune cell activation, and cytokine secretion, playing an essential role in inflammatory and immune-mediated diseases. It also contributes to cellular energy balance through its regulation of cAMP. Dysregulation of P2RY11 has been linked to autoimmune disorders, cardiac dysfunction, and inflammatory conditions. Targeting P2RY11 has potential therapeutic implications in immune modulation, cardiovascular diseases, and conditions associated with ATP-mediated inflammation.
Related Products
P2Y Purinoceptor 11 (P2RY11) Antibody
P2RY11 Antibody is a Rabbit Polyclonal antibody against P2RY11. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
Ver ProductoP2Y Purinoceptor 11 (P2RY11) Antibody
P2RY11 Antibody is a Rabbit Polyclonal antibody against P2RY11.
Ver ProductoP2Y Purinoceptor 11 (P2RY11) Antibody
P2RY11 Antibody is a Rabbit Polyclonal against P2RY11.
Ver Producto