Human Osteomodulin (OMD) Protein
702€ (50 µg)
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Name
Human Osteomodulin (OMD) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691802
Tested Applications
SDS-PAGE
Description
Human Osteomodulin Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human OMD (NP_005005.1) (Met1-Glu421) was expressed with a polyhistidine tag at the C-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Osteomodulin |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Glu421 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 48.6 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_005005.1 |
| Alias | OSAD,SLRR2C,KSPG osteomodulin,Osteoadherin |
| Background | Protein OMD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
Osteomodulin (OMD) is a small leucine-rich proteoglycan primarily expressed in the bone and cartilage, where it plays a key role in regulating extracellular matrix (ECM) structure and function OMD is involved in bone mineralization, collagen fibril organization, and cartilage development by interacting with collagen and other ECM components It contributes to skeletal integrity and has a significant impact on the mechanical properties of bone, influencing bone strength and elasticity OMD’s expression is upregulated during bone remodeling, and its role in cartilage integrity makes it crucial for joint health and skeletal repair Dysregulation of OMD expression has been associated with bone diseases such as osteogenesis imperfecta and osteoarthritis, where altered ECM composition leads to skeletal deformities and joint degradation Studies also suggest that OMD influences cell signaling pathways, particularly those related to osteoblast differentiation and function, highlighting its broader role in skeletal development and disease
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