Human Osteomodulin (OMD) Protein

Background

Osteomodulin (OMD) is a small leucine-rich proteoglycan primarily expressed in the bone and cartilage, where it plays a key role in regulating extracellular matrix (ECM) structure and function OMD is involved in bone mineralization, collagen fibril organization, and cartilage development by interacting with collagen and other ECM components It contributes to skeletal integrity and has a significant impact on the mechanical properties of bone, influencing bone strength and elasticity OMD’s expression is upregulated during bone remodeling, and its role in cartilage integrity makes it crucial for joint health and skeletal repair Dysregulation of OMD expression has been associated with bone diseases such as osteogenesis imperfecta and osteoarthritis, where altered ECM composition leads to skeletal deformities and joint degradation Studies also suggest that OMD influences cell signaling pathways, particularly those related to osteoblast differentiation and function, highlighting its broader role in skeletal development and disease