Human Nucleoporin 62 kDa (NUP62) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein NUP62
proveedor
Abbexareference
abx166991Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Nucleoporin 62 kDa Protein is a recombinant Human protein expressed in E. coli.
Background
Nucleoporin 62 (NUP62) is an essential member of the nuclear pore complex, playing a pivotal role in the selective transport of macromolecules across the nuclear envelope It facilitates the movement of RNA, proteins, and other molecules between the nucleus and cytoplasm, contributing to essential processes such as transcription, DNA replication, and cell cycle regulation NUP62 works in tandem with other nucleoporins to form the nuclear pore, allowing for controlled molecular trafficking essential for maintaining cellular function It interacts with various transport factors to regulate the export of RNA and ribosomal subunits to the cytoplasm, a key step in protein synthesis Dysregulation of NUP62 has been linked to numerous diseases, including cancers, where disruptions in nucleocytoplasmic transport lead to mislocalization of critical regulatory proteins, contributing to uncontrolled cell growth and survival Additionally, NUP62 is involved in cellular stress responses and repair mechanisms, emphasizing its role in tissue homeostasis and cell survival under adverse conditions The importance of NUP62 in gene regulation, protein synthesis, and cellular stress management highlights its central role in maintaining proper cellular function and tissue integrity
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Nucleoporin 62kDa (NUP62)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala186-Lys432 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
NUP62
dry ice
No
availability
Shipped within 5-7 working days.
alias
p62,IBSN,SNDI,nuclear pore glycoprotein p62,Nucleoporin Nup62
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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