Human Nucleoporin 62 kDa (NUP62) Protein

Product specifications

Proteins and Peptides

Nucleoporin 62kDa (NUP62)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 30.0 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ala186-Lys432
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P37198

p62,IBSN,SNDI,nuclear pore glycoprotein p62,Nucleoporin Nup62

Protein NUP62

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Nucleoporin 62 (NUP62) is an essential member of the nuclear pore complex, playing a pivotal role in the selective transport of macromolecules across the nuclear envelope It facilitates the movement of RNA, proteins, and other molecules between the nucleus and cytoplasm, contributing to essential processes such as transcription, DNA replication, and cell cycle regulation NUP62 works in tandem with other nucleoporins to form the nuclear pore, allowing for controlled molecular trafficking essential for maintaining cellular function It interacts with various transport factors to regulate the export of RNA and ribosomal subunits to the cytoplasm, a key step in protein synthesis Dysregulation of NUP62 has been linked to numerous diseases, including cancers, where disruptions in nucleocytoplasmic transport lead to mislocalization of critical regulatory proteins, contributing to uncontrolled cell growth and survival Additionally, NUP62 is involved in cellular stress responses and repair mechanisms, emphasizing its role in tissue homeostasis and cell survival under adverse conditions The importance of NUP62 in gene regulation, protein synthesis, and cellular stress management highlights its central role in maintaining proper cellular function and tissue integrity

Related Products

Human NUP62(Nucleoporin 62kDa) ELISA Kit

Ver Producto

Mouse NUP62(nucleoporin p62) ELISA Kit

Ver Producto

anti- NUP62 antibody

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.

Ver Producto