Human Nucleoporin 153 kDa (NUP153) Protein
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Description
Nucleoporin 153 kDa Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nucleoporin 153kDa (NUP153) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 55.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser1238-Lys1468 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49790 |
| Alias | N153,HNUP153,nucleoporin 153kDa,Nuclear pore complex protein Nup153 |
| Background | Protein NUP153 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Nucleoporin 153 (NUP153) is an essential component of the nuclear pore complex (NPC) that plays a significant role in nucleocytoplasmic transport NUP153 is involved in the structural maintenance of the NPC and aids in the selective trafficking of proteins, RNA, and ribosomal subunits across the nuclear envelope It functions as an anchor point for other nucleoporins, stabilizing the nuclear pore structure and facilitating the proper exchange of molecules between the nucleus and cytoplasm NUP153 also participates in the regulation of gene expression, ensuring the efficient export of mRNA from the nucleus to the cytoplasm for translation During cell division, NUP153 helps maintain nuclear envelope integrity, ensuring proper nuclear compartmentalization and cell cycle progression Dysregulation of NUP153 has been linked to various diseases, including cancers and neurodegenerative disorders, where faulty nuclear transport can disrupt cellular processes, leading to genomic instability and abnormal cell proliferation
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