Human Noggin (NOG) ELISA Kit
585€ (96 tests)
585€ (96 tests)
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name
Human Noggin (NOG) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx250292
tested applications
ELISA
Descripción del producto
Human Noggin (NOG) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Noggin concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Especificaciones del producto
| OMIM | 184460 |
| Alias | SYM1, SYNS1,SYNS1A |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Background | Elisa kits for NOG |
| Category | ELISA Kits |
| Detection Method | Colorimetric |
| Dry Ice | No |
| Form | Lyophilized |
| Immunogen Target | Noggin (NOG) |
| Name | Human Noggin (NOG) ELISA Kit |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Price | 585 |
| Provider | Abbexa |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx250292 |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Sensitivity | 75 pg/ml |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Status | RUO |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Test Range | 125 pg/ml - 8000 pg/ml |
| Tested Applications | ELISA |
| UniProt ID | Q13253 |
Descripcion del producto en español
Background en español
Noggin (NOG) is a secreted glycoprotein that plays a critical role in regulating embryonic development and tissue homeostasis. It functions as an antagonist of bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-β) superfamily. By binding directly to BMPs such as BMP-2, BMP-4, and BMP-7, Noggin inhibits their ability to interact with receptors on the cell surface, thereby preventing the activation of downstream signaling pathways. This modulation is essential for proper skeletal development, including joint formation and bone growth, as well as the differentiation of neural and mesenchymal tissues. Noggin is expressed in various embryonic structures, including the notochord and somites, and its spatial and temporal expression is tightly regulated to ensure normal development. Mutations or dysregulation of NOG can result in skeletal disorders such as symphalangism and multiple synostoses syndrome. Noggin has also been implicated in processes like wound healing, cancer, and fibrosis, where BMP signaling plays a role. As a therapeutic target, Noggin's ability to modulate BMP activity makes it a potential candidate for treating conditions like osteoporosis and fibrodysplasia ossificans progressiva (FOP). Its role in tissue engineering and regenerative medicine is also being explored.
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