Human NKG2-C Type II Integral Membrane Protein (KLRC2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for KLRC2
proveedor
Abbexareference
abx535335Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human NKG2-C Type II Integral Membrane Protein (KLRC2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human NKG2-C Type II Integral Membrane Protein (KLRC2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Killer cell lectin like receptor C2 (KLRC2), commonly referred to as NKG2C, is an activating receptor expressed on NK cells and some T cells. Unlike KLRC1, KLRC2 interacts with HLA-E to initiate stimulatory signals that enhance cytotoxic responses and cytokine production. KLRC2 signaling is mediated through its association with the adaptor molecule DAP12, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) responsible for triggering downstream signaling cascades. This receptor is pivotal in the immune response against infected or transformed cells, particularly in conditions where HLA-E is overexpressed due to stress or infection. KLRC2 is also involved in adaptive immune responses, contributing to the expansion and memory-like properties of NK cells, especially during cytomegalovirus (CMV) infections. Targeting KLRC2 pathways is being explored to potentiate immune responses in infectious diseases and cancer therapies.
Características del producto
category
ELISA Kits
immunogen target
NKG2-C Type II Integral Membrane Protein (KLRC2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
NKG2-C type II integral membrane protein,NKG2C,CD159c,NKG2-C,CD159 antigen-like family member C,NK cell receptor C,NKG2-C-activating NK receptor
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
KLRC2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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