Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) CLIA Kit
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Description
Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Neutral Sphingomyelinase Activation Associated Factor (NSMAF) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.054 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | FAN,GRAMD5,Protein FAN |
| Background | CLIA Kits NSMAF |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Neutral sphingomyelinase activation associated factor (NSMAF) is a key protein involved in the regulation of sphingomyelin metabolism, specifically in the activation of neutral sphingomyelinase (nSMase). This enzyme plays an important role in generating ceramide, a lipid molecule involved in various cellular processes, including apoptosis, cell differentiation, and membrane integrity. NSMAF functions as an activator of nSMase, and its activity is crucial for the proper regulation of sphingomyelinase signaling pathways. The activation of nSMase by NSMAF is essential for maintaining cellular homeostasis and regulating lipid metabolism, especially in response to external stimuli such as oxidative stress or inflammatory signals. Disruption of NSMAF function can lead to abnormal ceramide production, which has been linked to several diseases, including neurodegenerative conditions, cancers, and metabolic disorders. Understanding the role of NSMAF in sphingomyelinase regulation is important for developing potential therapeutic strategies targeting ceramide-related pathways in various diseases.
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