Human Neuropilin 1 (NRP1) Protein

Product specifications

Proteins and Peptides

Neuropilin 1 (NRP1)

E. coli

Activity: Not tested
Sequence Fragment: Phe22-Ser641
Tag: N-terminal His tag

Optimal dilutions/concentrations should be determined by the end user.

Human

Unconjugated

Calculated MW: 71.89 kDa

Recombinant

> 90% (SDS-PAGE)

50 µg

100 µg

1 mg

Lyophilized

ELISA, WB, SDS-PAGE

Prior to lyophilization: PBS pH 7.4, containing 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Shipped within 5-10 working days.

Aliquot and store at -20 °C to 80°C. Avoid repeated freeze-thaw cycles.
Shelf Life: 12 months.

No

O14786

8829

NP_001019799.1,NP_001019799.2,NP_001019800.1,NP_001019800.2,NP_001316997.1,NP_003864.4

Vascular endothelial cell growth factor 165 receptor,NP1,NRP,BDCA4,CD304,VEGF165R,

Protein NRP1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile water to produce a stock solution.

Descripción

Neuropilin-1 (NRP1) is a multifunctional transmembrane glycoprotein that plays critical roles in multiple physiological processes, including vascular development, neural guidance, immune modulation, and cancer progression. First characterized as a receptor involved in the guidance of axons, NRP1 is now known to act as a co-receptor for various ligands, including vascular endothelial growth factor (VEGF) and semaphorin family proteins, which control angiogenesis and axonal guidance, respectively. NRP1 is widely expressed in endothelial cells, neurons, immune cells, and several tumor cell types. Its role in mediating signal transduction for multiple growth factors makes it highly significant in both normal developmental biology and pathologies, including cancer and cardiovascular diseases. NRP1’s structure allows it to interact with a variety of ligands, facilitating its participation in different signaling pathways. Importantly, NRP1 lacks intrinsic kinase activity and instead functions by associating with other receptor complexes. This co-receptor capability is vital for its role in angiogenesis, where it enhances VEGF signaling by complexing with VEGF receptors (particularly VEGFR2), and in immune regulation, where it modulates T cell activity and antigen presentation. NRP1 has therefore become a target of interest for therapeutic intervention in diseases involving abnormal cell growth, such as cancer and chronic inflammatory conditions.

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