Human Neurofibromin 2 (NF2) Protein
234€ (10 µg)
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Name
Human Neurofibromin 2 (NF2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068243
Tested Applications
WB, SDS-PAGE
Description
Human Neurofibromin 2 (NF2) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Neurofibromin 2 (NF2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Asp30-Leu239 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 28.6 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35240 |
| Alias | ACN,SCH,BANF,SWNV,merlin-1,Merlin,Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomerlin,Schwannomin |
| Background | Protein NF2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (NF2) is another critical tumor suppressor protein that functions as part of the NF2 gene, playing a key role in regulating cell-cell contact, maintaining cell adhesion, and controlling cell growth MERLIN, as a homolog of the ERM (ezrin-radixin-moesin) family of proteins, is involved in linking the actin cytoskeleton to the plasma membrane and plays a role in cellular processes such as migration, differentiation, and response to growth signals MERLIN acts as a tumor suppressor by inhibiting uncontrolled cell division and preventing the formation of tumors, particularly in the nervous system, where mutations in NF2 lead to the development of benign tumors known as schwannomas, including vestibular schwannomas, which affect hearing and balance MERLIN’s interaction with other signaling pathways, including the Hippo pathway, further strengthens its role in controlling cell proliferation and apoptosis Dysregulation of MERLIN signaling due to NF2 mutations contributes to the formation of tumors, making NF2 an important gene in the context of cancer research and therapeutic development
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