Human Neurofibromin 2 (NF2) CLIA Kit

Este producto es parte de NF - neurofibromin/merlin
Human Neurofibromin 2 (NF2) CLIA Kit
845€ (96 tests)

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Name
Human Neurofibromin 2 (NF2) CLIA Kit
Category
CLIA Kits
Provider
Abbexa
Reference
abx493281
Tested Applications
CLIA

Description

Human Neurofibromin 2 (NF2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
CLIA Kits
Immunogen Target
Neurofibromin 2 (NF2)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.117 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard: Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
ACN,SCH,BANF,SWNV,merlin-1,Merlin,Moesin-ezrin-radixin-like protein,Neurofibromin-2,Schwannomerlin,Schwannomin
Background
CLIA Kits NF2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.  Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (NF2) is another critical tumor suppressor protein that functions as part of the NF2 gene, playing a key role in regulating cell-cell contact, maintaining cell adhesion, and controlling cell growth MERLIN, as a homolog of the ERM (ezrin-radixin-moesin) family of proteins, is involved in linking the actin cytoskeleton to the plasma membrane and plays a role in cellular processes such as migration, differentiation, and response to growth signals MERLIN acts as a tumor suppressor by inhibiting uncontrolled cell division and preventing the formation of tumors, particularly in the nervous system, where mutations in NF2 lead to the development of benign tumors known as schwannomas, including vestibular schwannomas, which affect hearing and balance MERLIN’s interaction with other signaling pathways, including the Hippo pathway, further strengthens its role in controlling cell proliferation and apoptosis Dysregulation of MERLIN signaling due to NF2 mutations contributes to the formation of tumors, making NF2 an important gene in the context of cancer research and therapeutic development

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