Human Neuritin 1 (NRN1) Protein

Product specifications

Proteins and Peptides

Neuritin 1 (NRN1)

Activity: Active
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Human

Unconjugated

Recombinant

> 90%

50 µg

100 µg

200 µg

500 µg

1 mg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

NRN

Protein NRN1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

Neuritin 1 (NRN1) is a protein encoded by the NRN1 gene and plays a significant role in neural development, synaptic plasticity, and neuronal regeneration, being highly expressed in the brain, particularly in regions associated with neurogenesis such as the hippocampus and cerebral cortex. It is induced by neural activity and neurotrophic factors, mediating processes like axonal growth, dendritic arborization, and synaptogenesis, which are crucial for learning and memory. NRN1 acts as a glycosylphosphatidylinositol (GPI)-anchored protein on the neuronal membrane, influencing cell-cell interactions and extracellular signaling, particularly in response to stimuli like injury or ischemic events. Dysregulation of NRN1 expression has been linked to neurodegenerative disorders and psychiatric conditions such as Alzheimer's disease, schizophrenia, and depression, indicating its role in maintaining neural integrity and adaptability. In experimental models, NRN1 has shown potential in promoting axonal regeneration and functional recovery following nerve injury, highlighting its therapeutic relevance. Elevated NRN1 expression correlates with increased neuronal survival and plasticity, while its suppression can impair cognitive and motor functions, illustrating its pivotal role in sustaining neurophysiological processes

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