Neuritin 1 (NRN1) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Neuritin 1 (NRN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104984
tested applications
WB, IHC
Description
Neuritin 1 (NRN1) Antibody is a Rabbit polyclonal against Human Neuritin 1 (NRN1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Neuritin 1 (NRN1) Immunogen: abx166499 - Recombinant Human NRN1 (Ala28-Phe142) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NPD7 |
| Gene ID | 51299 |
| Alias | NRN |
| Background | Antibody anti-NRN1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Neuritin 1 (NRN1) is a protein encoded by the NRN1 gene and plays a significant role in neural development, synaptic plasticity, and neuronal regeneration, being highly expressed in the brain, particularly in regions associated with neurogenesis such as the hippocampus and cerebral cortex. It is induced by neural activity and neurotrophic factors, mediating processes like axonal growth, dendritic arborization, and synaptogenesis, which are crucial for learning and memory. NRN1 acts as a glycosylphosphatidylinositol (GPI)-anchored protein on the neuronal membrane, influencing cell-cell interactions and extracellular signaling, particularly in response to stimuli like injury or ischemic events. Dysregulation of NRN1 expression has been linked to neurodegenerative disorders and psychiatric conditions such as Alzheimer's disease, schizophrenia, and depression, indicating its role in maintaining neural integrity and adaptability. In experimental models, NRN1 has shown potential in promoting axonal regeneration and functional recovery following nerve injury, highlighting its therapeutic relevance. Elevated NRN1 expression correlates with increased neuronal survival and plasticity, while its suppression can impair cognitive and motor functions, illustrating its pivotal role in sustaining neurophysiological processes
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