Human Neuregulin 2 (NRG2) Protein
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Description
Human Neuregulin 2 (NRG2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Neuregulin 2 (NRG2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 13.3 kDa Observed MW (SDS-PAGE): 14 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe101-Phe211 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14511 |
| Gene ID | 9542 |
| OMIM | 603818 |
| Alias | DON1,HRG2,NTAK,Pro-NRG2,Pro-neuregulin-2 membrane-bound isoform,Divergent of neuregulin-1,Neural- and thymus-derived activator for ERBB kinases |
| Background | Protein NRG2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Neuregulin 2 (NRG2), though structurally similar to NRG1, displays distinct expression patterns and specialized functions. Predominantly found in the brain, NRG2 is integral to synaptic stability, neurotransmission, and neural development. By signaling through ErbB receptor pathways, NRG2 contributes to the interactions between neurons and glial cells, thus supporting neural network formation and maintenance. Research has begun to associate NRG2 with neuropsychiatric disorders, cognitive processes, and neuroplasticity. These emerging links make it a promising area for exploration in understanding the mechanisms underlying mental health conditions and potential therapeutic interventions.
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Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
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