Human Neuregulin 2 (NRG2) CLIA Kit
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Description
Human Neuregulin 2 (NRG-2) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Neuregulin 2 (NRG-2).
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Neuregulin 2 (NRG2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | 18.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | DON1,HRG2,NTAK,Pro-NRG2,Pro-neuregulin-2 membrane-bound isoform,Divergent of neuregulin-1,Neural- and thymus-derived activator for ERBB kinases |
| Background | CLIA Kits NRG2 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Neuregulin 2 (NRG2), though structurally similar to NRG1, displays distinct expression patterns and specialized functions. Predominantly found in the brain, NRG2 is integral to synaptic stability, neurotransmission, and neural development. By signaling through ErbB receptor pathways, NRG2 contributes to the interactions between neurons and glial cells, thus supporting neural network formation and maintenance. Research has begun to associate NRG2 with neuropsychiatric disorders, cognitive processes, and neuroplasticity. These emerging links make it a promising area for exploration in understanding the mechanisms underlying mental health conditions and potential therapeutic interventions.
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Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
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