Human Neural Cell Adhesion Molecule 2 (NCAM2) Protein
234€ (10 µg)
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935106861
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name
Human Neural Cell Adhesion Molecule 2 (NCAM2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166894
tested applications
WB, SDS-PAGE
Description
Human Neural Cell Adhesion Molecule 2 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Neural Cell Adhesion Molecule 2 (NCAM2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 60.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu21-Gln297 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15394 |
| Gene ID | 4685 |
| Alias | NCAM21,N-CAM-2 |
| Background | Protein NCAM2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Neural Cell Adhesion Molecule 2 (NCAM2), also known as OCAM (Olfactory Cell Adhesion Molecule), is another member of the immunoglobulin (Ig) superfamily that mediates cell adhesion and neuronal connectivity. NCAM2 shares structural similarities with NCAM1, including five Ig-like domains and two fibronectin type III domains in its extracellular region. However, NCAM2 has distinct roles in the olfactory system and brain development. It is highly expressed in olfactory neurons, where it regulates axon guidance and synaptic targeting. NCAM2 is crucial for neuronal differentiation and the establishment of specific neural circuits, particularly in the hippocampus and olfactory bulb. It mediates homophilic binding (interaction with identical molecules) to promote cell adhesion and structural organization. In the brain, NCAM2 is essential for the maintenance of synaptic connections and proper cortical layering.
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