Human Natural Killer Cell Receptor 2B4 (CD244) Protein (Active)
1118€ (100 µg)
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Name
Human Natural Killer Cell Receptor 2B4 (CD244) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691012
Tested Applications
SDS-PAGE
Description
Natural Killer Cell Receptor 2B4 (CD244) protein is a recombinant Human protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Natural Killer Cell Receptor 2B4 (CD244) |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Arg221 Tag: C-terminal Fc tag |
| Origin | Human |
| Observed MW | 49 kDa |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9BZW8 |
| Gene ID | 51744 |
| NCBI Accession | NP_057466.1 |
| OMIM | 605554 |
| Alias | Natural killer cell receptor 2B4,2B4,NAIL,Nmrk,NKR2B4,SLAMF4,NK cell activation-inducing ligand,SLAM family member 4,Signaling lymphocytic activation molecule 4 |
| Background | Protein CD244 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
CD244, also known as 2B4, is a receptor primarily expressed on natural killer (NK) cells and subsets of T cells. CD244 is encoded by the CD244 gene and belongs to the Signaling Lymphocyte Activation Molecule (SLAM) family within the immunoglobulin superfamily. This receptor plays a key role in immune regulation, functioning as a modulator of cytotoxic responses against infected or malignant cells. CD244 interacts with its ligand, CD48, a widely expressed protein found on hematopoietic cells, allowing it to mediate immune surveillance and inflammatory responses. CD244 has gained significant attention due to its dual role as an activating and inhibitory receptor on immune cells, where its function depends largely on the cellular context and specific signal cascades involved. Unlike many receptors that have a straightforward activating or inhibitory role, CD244 is unique in its ability to modulate immune responses through varying interactions with different proteins in NK cells and T cells.
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