Human Natriuretic Peptides B (NPPB) Protein
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Description
Natriuretic Peptides B (NPPB) Protein is a partly glycosylated recombinant protein consisting of amino acids 27-134 of full length Human NPPB/proBNP.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Natriuretic Peptides B (NPPB) |
| Host | Mammalian cells |
| Assay Type | Sequence Fragment: 27-134 AA. |
| Origin | Human |
| Observed MW | Calculated MW: 20-25 kDa. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by ion exchange chromatography. |
| Size 1 | 0.1 mg |
| Form | Lyophilized |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store lyophilized at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16860 |
| Background | Protein NPPB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in deionized water. It is recommended to dilute the product further in 0.05 M Tris-HCl, pH 7.8, containing 0.15 M NaCl, 0.01% Tween 40, 0.5% BSA. |
Descripción
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NPPB antibody
NPPB, also known as B-type natriuretic peptide (BNP), is a cardiac hormone that is secreted mainly in the ventricles in response to increased wall stress. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. BNP is a marker of systolic and diastolic dysfunction and a strong predictor of mortality in heart failure patients.
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Natriuretic Peptides B (NPPB) Antibody
NPPB Antibody is a Rabbit Polyclonal antibody against NPPB. This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
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Natriuretic Peptides B (NPPB) Antibody
Natriuretic Peptides B (NPPB) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. BNP circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. It is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic.
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