Human Myosin Light Chain Kinase 2 (MYLK2) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Human Myosin Light Chain Kinase 2 (MYLK2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166940
tested applications
WB, SDS-PAGE
Description
Myosin Light Chain Kinase 2 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Myosin Light Chain Kinase 2 (MYLK2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 32.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala313-Lys562 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | KMLC,MLCK,MLCK2,skMLCK,Myosin light chain kinase 2, skeletal cardiac muscle |
| Background | Protein MYLK2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Myosin light chain kinase 2 (MYLK2) is a muscle-specific isoform of myosin light chain kinase predominantly expressed in skeletal muscle tissue. MYLK2 plays a key role in regulating myosin activity during muscle contraction by phosphorylating the regulatory light chains of myosin II, a process critical for force generation and sarcomere function. The kinase activity of MYLK2 is tightly regulated by calcium-calmodulin signaling, ensuring precise control of contractile responses during dynamic skeletal muscle activities such as exercise and locomotion. MYLK2 also contributes to the adaptive remodeling of muscle fibers in response to mechanical stress and physiological demands. Mutations or dysregulation of MYLK2 have been associated with myopathies and muscle weakness, emphasizing its essential role in maintaining muscular integrity and function.
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