Human Multidrug Resistance Associated Protein 1 (ABCC1) CLIA Kit

Este producto es parte de ABCC - ATP binding cassette subfamily C
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Human Multidrug Resistance Associated Protein 1 (ABCC1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx197314
tested applications
CLIA

Description

Human Multidrug Resistance Associated Protein 1 (MRP1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Multidrug Resistance Associated Protein 1 (MRP1).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Multidrug Resistance Associated Protein 1 (ABCC1)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
62.5 pg/ml - 4000 pg/ml
Sensitivity
37.5 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
ABC29,ABCC,DFNA77,GS-X,MRP,MRP1
Background
CLIA Kits ABCC1
Status
RUO
Note
The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ABCC1, also known as multidrug resistance-associated protein 1 (MRP1), is a transmembrane ATP-binding cassette transporter that effluxes a wide range of substrates, including drugs, xenobiotics, and endogenous molecules such as glutathione, leukotrienes, and conjugated metabolites. It is highly expressed in barrier tissues, such as the blood-brain barrier, lungs, and liver, where it protects cells by exporting potentially toxic compounds. ABCC1 plays a key role in multidrug resistance, as its overexpression in cancer cells reduces the efficacy of chemotherapeutic agents by actively transporting them out of cells. Structurally, ABCC1 contains two transmembrane domains and two ATP-binding domains that enable ATP-driven substrate transport. Dysregulation of ABCC1 activity is implicated in various pathological conditions, including drug resistance, inflammation, and oxidative stress, making it a target for therapeutic intervention in oncology and pharmacology.

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