Human Mucin 1 (MUC1) CLIA Kit

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Description
Human Mucin 1 (MUC1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Mucin 1 (MUC1).
Documents del producto
Product specifications
Category | CLIA Kits |
Immunogen Target | Mucin 1 (MUC1) |
Reactivity | Human |
Detection Method | Chemiluminescent |
Assay Data | Quantitative |
Assay Type | Sandwich |
Test Range | 31.2 pg/ml - 2000 pg/ml |
Sensitivity | 18.8 pg/ml |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 96 tests |
Form | Lyophilized |
Tested Applications | CLIA |
Sample Type | Serum, plasma and other biological fluids. |
Availability | Shipped within 5-12 working days. |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Dry Ice | No |
UniProt ID | P15941 |
Gene ID | 4582 |
NCBI Accession | NP_001018016.1, NM_001018016.2 |
OMIM | 113720 |
Alias | Cancer antigen 15-3,CA 15-3,EMA,MCD,PEM,PUM,KL-6,MAM6,MCKD,PEMT,CD227,H23AG,MCKD1,MUC-1,ADMCKD, ADTKD2,Ca15-3,MUC-1,Episialin |
Background | CLIA Kits MUC1 |
Status | RUO |
Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
MUC1 (Mucin 1) is a large, transmembrane glycoprotein predominantly expressed on the surface of epithelial cells in various tissues, including the lungs, stomach, intestines, and the mammary glands. As a mucin protein, MUC1 plays a critical role in forming a protective mucous barrier on epithelial surfaces, which protects against environmental and microbial challenges. MUC1 also contributes to cell signaling and modulation of the immune response, particularly in epithelial cell inflammation. Due to its protective function on epithelial tissues, MUC1 expression is typically restricted to the apical surface of cells. However, in pathological states like cancer, MUC1 expression becomes dysregulated. Overexpression, aberrant glycosylation, and loss of polarity are commonly observed in many epithelial cancers, including breast, ovarian, and pancreatic cancers. These modifications contribute to tumor development, cancer cell survival, and metastasis, making MUC1 a key target for cancer diagnostics and therapeutics. In addition to cancer, MUC1 is associated with certain inflammatory and infectious diseases due to its role in the immune system.
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