Human Mucin 1 (MUC1) CLIA Kit

Product specifications

CLIA Kits

Mucin 1 (MUC1)

Human

Chemiluminescent

Quantitative

Sandwich

31.2 pg/ml - 2000 pg/ml

18.8 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

CLIA

Serum, plasma and other biological fluids.

Shipped within 5-12 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P15941

4582

NP_001018016.1, NM_001018016.2

113720

Cancer antigen 15-3,CA 15-3,EMA,MCD,PEM,PUM,KL-6,MAM6,MCKD,PEMT,CD227,H23AG,MCKD1,MUC-1,ADMCKD, ADTKD2,Ca15-3,MUC-1,Episialin

CLIA Kits MUC1

RUO

The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

MUC1 (Mucin 1) is a large, transmembrane glycoprotein predominantly expressed on the surface of epithelial cells in various tissues, including the lungs, stomach, intestines, and the mammary glands. As a mucin protein, MUC1 plays a critical role in forming a protective mucous barrier on epithelial surfaces, which protects against environmental and microbial challenges. MUC1 also contributes to cell signaling and modulation of the immune response, particularly in epithelial cell inflammation. Due to its protective function on epithelial tissues, MUC1 expression is typically restricted to the apical surface of cells. However, in pathological states like cancer, MUC1 expression becomes dysregulated. Overexpression, aberrant glycosylation, and loss of polarity are commonly observed in many epithelial cancers, including breast, ovarian, and pancreatic cancers. These modifications contribute to tumor development, cancer cell survival, and metastasis, making MUC1 a key target for cancer diagnostics and therapeutics. In addition to cancer, MUC1 is associated with certain inflammatory and infectious diseases due to its role in the immune system.

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The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

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