Human Motilin receptor (MLNR) ELISA Kit
715€ (96 tests)
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name
Human Motilin receptor (MLNR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx533920
tested applications
ELISA
Description
Human Motilin receptor (MLNR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Motilin receptor (MLNR) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Motilin receptor (MLNR) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O43193 |
| Gene ID | 2862 |
| OMIM | 602885 |
| Alias | MLNR,GRM,GPR38,G protein-coupled receptor 38,MOT-R,MTLR ,MTLR1 |
| Background | Elisa Kits for: MLNR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
The motilin receptor (MLNR) is a G protein-coupled receptor (GPCR) primarily expressed in the gastrointestinal tract, where it is activated by motilin, a 22-amino acid peptide hormone. MLNR is predominantly located in the smooth muscle of the stomach and upper small intestine, where it regulates gastrointestinal motility and the migrating motor complex (MMC) during fasting. Activation of MLNR triggers Gq-mediated signaling pathways, leading to increased intracellular calcium levels, smooth muscle contraction, and enhanced peristalsis. MLNR plays a key role in initiating gastric emptying and maintaining gut motility. It is a critical target for prokinetic agents such as erythromycin, which mimic motilin's action to stimulate gastric motility in conditions like gastroparesis. Dysregulation of MLNR is associated with gastrointestinal motility disorders, including delayed gastric emptying and functional dyspepsia. MLNR agonists continue to be explored for therapeutic applications to restore gut motility and improve gastrointestinal function in motility-related disorders.
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