Human Monocyte Differentiation Antigen CD14 (CD14) Protein

Este producto es parte de CD14 - Cluster of Differentiation 14
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481€ (20 µg)

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935106861
info@markelab.com
name
Human Monocyte Differentiation Antigen CD14 (CD14) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694192
tested applications
SDS-PAGE

Description

Human Monocyte Differentiation Antigen CD14 (CD14) Protein is a recombinant Human protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: Calculated MW: 37.73 kDa  Observed MW (SDS-PAGE): 45 kDa
Sequence Fragment: Met1-Met344
Tag: C-terminal His tag
Expression
Recombinant
Purity
>95% (SDS-PAGE)
Size 1
20 µg
Size 2
100 µg
Form
Lyophilized Reconstitute in sterile H2O. Do not vortex.
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
Availability
Shipped within 5-15 working days.
Storage
Store lyophilized between -20 °C and -80 °C.
Dry Ice
No
UniProt ID
P08571
Alias
Cluster Of Differentiation 14,CD14,Myeloid Cell-Specific Leucine-Rich Glycoprotein,Monocyte differentiation antigen CD14
Background
Protein CD14
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CD14 is a pattern recognition receptor (PRR) expressed on the surface of monocytes, macrophages, and neutrophils, where it plays a key role in the innate immune response CD14 functions as a co-receptor for the detection of lipopolysaccharides (LPS) derived from the outer membrane of Gram-negative bacteria It forms a complex with LPS-binding protein (LBP) and transduces signals via the Toll-like receptor 4 (TLR4)-MD2 complex, initiating downstream activation of nuclear factor kappa B (NF-κB) and subsequent production of pro-inflammatory cytokines CD14 exists in two forms, a membrane-bound form (mCD14) and a soluble form (sCD14), both of which contribute to LPS recognition and systemic inflammatory responses Dysregulation of CD14 signaling has been implicated in sepsis, chronic inflammatory diseases, and autoimmune disorders Elevated levels of soluble CD14 serve as a biomarker for monocyte activation in conditions such as HIV, cardiovascular disease, and metabolic disorders

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