Human Ragulator Complex Protein LAMTOR3 / MAPKSP1 (LAMTOR3) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein LAMTOR3
proveedor
Abbexareference
abx068043Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Mitogen Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Ragulator complex protein LAMTOR3 is an integral subunit of the lysosomal Ragulator complex that functions as a critical activator of the mTORC1 pathway in response to amino acid and nutrient signaling LAMTOR3 is required for the localization of Rag GTPases to the lysosomal surface, which facilitates the recruitment of mTORC1 and its activation upon nutrient availability Beyond its role in nutrient sensing, LAMTOR3 regulates lysosomal positioning and intracellular trafficking processes Dysregulation of LAMTOR3 disrupts mTOR signaling and has been linked to cellular growth defects, metabolic disorders, and tumor progression Studies highlight its role in maintaining energy balance and cell survival under stress conditions LAMTOR3 also participates in immune cell responses, as mTORC1 signaling is vital for T-cell activation and differentiation Its involvement in nutrient sensing and cellular homeostasis underscores its importance in both normal physiology and disease pathogenesis
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Ragulator Complex Protein LAMTOR3 / MAPKSP1 (LAMTOR3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 17.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser124 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
LAMTOR3
dry ice
No
availability
Shipped within 5-7 working days.
alias
MAP2K1IP1,MAPBP,MAPKSP1,MP1,PRO0633,Ragulator3,Mitogen-activated protein kinase scaffold protein 1,late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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