Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Methylcytosine dioxygenase TET1 (TET1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Methylcytosine dioxygenase TET1 (TET1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8NFU7 |
| OMIM | 607790 |
| Alias | CXXC6,LCX,bA119F7.1,CXXC-type zinc finger protein 6,Leukemia-associated protein with a CXXC domain |
| Background | Elisa kits for TET1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TET1 is a member of the TET protein family that plays a crucial role in DNA demethylation and epigenetic regulation. TET1 catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in the active DNA demethylation pathway, thereby influencing gene expression and chromatin remodeling. TET1 is highly expressed in embryonic stem cells and early development, where it maintains pluripotency, regulates differentiation, and ensures proper gene activation. It functions in tandem with transcription factors and chromatin modifiers to regulate lineage specification, DNA repair, and cellular reprogramming. Dysregulation of TET1 is associated with cancers, including leukemia, where altered DNA methylation patterns contribute to tumorigenesis. Additionally, TET1 is implicated in neurological disorders and aging, where its loss disrupts epigenetic homeostasis. Knockout studies show impaired stem cell self-renewal, aberrant gene silencing, and developmental defects, underscoring TET1's essential role in DNA methylation dynamics, epigenetic reprogramming, and cellular identity maintenance.
Related Products
Human TET1 (Methylcytosine dioxygenase TET1) ELISA Kit
Ver Producto
Methylcytosine Dioxygenase TET1 (TET1) Antibody
TET1 Antibody is a Rabbit Polyclonal antibody against TET1. TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Ver Producto
Methylcytosine Dioxygenase TET1 (TET1) Antibody
TET1 Antibody is a Rabbit Polyclonal against TET1.
Ver Producto