Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit

Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for TET1

proveedor

Abbexa

reference

abx549337

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Methylcytosine dioxygenase TET1 (TET1) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

TET1 is a member of the TET protein family that plays a crucial role in DNA demethylation and epigenetic regulation. TET1 catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in the active DNA demethylation pathway, thereby influencing gene expression and chromatin remodeling. TET1 is highly expressed in embryonic stem cells and early development, where it maintains pluripotency, regulates differentiation, and ensures proper gene activation. It functions in tandem with transcription factors and chromatin modifiers to regulate lineage specification, DNA repair, and cellular reprogramming. Dysregulation of TET1 is associated with cancers, including leukemia, where altered DNA methylation patterns contribute to tumorigenesis. Additionally, TET1 is implicated in neurological disorders and aging, where its loss disrupts epigenetic homeostasis. Knockout studies show impaired stem cell self-renewal, aberrant gene silencing, and developmental defects, underscoring TET1's essential role in DNA methylation dynamics, epigenetic reprogramming, and cellular identity maintenance.

Características del producto

category

ELISA Kits


immunogen target

Methylcytosine dioxygenase TET1 (TET1)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.07 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

CXXC6,LCX,bA119F7.1,CXXC-type zinc finger protein 6,Leukemia-associated protein with a CXXC domain


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

TET1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


Quizá le pueda interesar

Methylcytosine Dioxygenase TET1 (TET1) Antibody

Methylcytosine Dioxygenase TET1 (TET1) Antibody

proveedor

Abbexa

reference

abx001270

Tested Applications

WB, IHC, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

TET1 Antibody is a Rabbit Polyclonal antibody against TET1. TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,13...

312€ (60 µl)

Ver más

Methylcytosine Dioxygenase TET1 (TET1) Antibody

Methylcytosine Dioxygenase TET1 (TET1) Antibody

proveedor

Abbexa

reference

abx313737

Tested Applications

ELISA, IHC

reactivity

Human

status

RUO

clonality

Polyclonal

TET1 Antibody is a Rabbit Polyclonal against TET1.

169€ (20 µg)

Ver más

Methylcytosine Dioxygenase TET1 (TET1) Antibody (HRP)

Methylcytosine Dioxygenase TET1 (TET1) Antibody (HRP)

proveedor

Abbexa

reference

abx313738

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Polyclonal

TET1 Antibody (HRP) is a Rabbit Polyclonal against TET1 conjugated to HRP.

169€ (20 µg)

Ver más