Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TET1
proveedor
Abbexareference
abx549337Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Methylcytosine dioxygenase TET1 (TET1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Methylcytosine dioxygenase TET1 (TET1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TET1 is a member of the TET protein family that plays a crucial role in DNA demethylation and epigenetic regulation. TET1 catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in the active DNA demethylation pathway, thereby influencing gene expression and chromatin remodeling. TET1 is highly expressed in embryonic stem cells and early development, where it maintains pluripotency, regulates differentiation, and ensures proper gene activation. It functions in tandem with transcription factors and chromatin modifiers to regulate lineage specification, DNA repair, and cellular reprogramming. Dysregulation of TET1 is associated with cancers, including leukemia, where altered DNA methylation patterns contribute to tumorigenesis. Additionally, TET1 is implicated in neurological disorders and aging, where its loss disrupts epigenetic homeostasis. Knockout studies show impaired stem cell self-renewal, aberrant gene silencing, and developmental defects, underscoring TET1's essential role in DNA methylation dynamics, epigenetic reprogramming, and cellular identity maintenance.
Características del producto
category
ELISA Kits
immunogen target
Methylcytosine dioxygenase TET1 (TET1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.07 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
CXXC6,LCX,bA119F7.1,CXXC-type zinc finger protein 6,Leukemia-associated protein with a CXXC domain
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TET1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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