Human Metabotropic glutamate receptor 8 (GRM8) ELISA Kit
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Description
Human Metabotropic glutamate receptor 8 (GRM8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Metabotropic glutamate receptor 8 (GRM8) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Metabotropic glutamate receptor 8 (GRM8) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O00222 |
| Gene ID | 2918 |
| OMIM | 601116 |
| Alias | GRM8,GLUR8,GPRC1H,MGLUR8,mGlu8 |
| Background | Elisa kits for GRM8 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GRM8, or mGluR8, is a Group III metabotropic glutamate receptor expressed predominantly in the hippocampus, thalamus, and olfactory bulb, where it functions as a presynaptic receptor to inhibit glutamate release. GRM8 couples to Gi/o proteins, suppressing adenylate cyclase activity and cAMP production, thereby regulating synaptic transmission and reducing excitotoxicity. GRM8 plays a role in modulating synaptic plasticity, sensory processing, and neuroprotection. Dysregulation of GRM8 is associated with neurological disorders, including epilepsy, chronic pain, and anxiety, where impaired glutamate regulation contributes to neuronal hyperexcitability. GRM8 also exhibits potential in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease, where its activation provides neuroprotective effects. Positive allosteric modulators (PAMs) and selective agonists of GRM8 are being developed to restore glutamatergic balance and protect against excitotoxic damage, positioning it as a promising therapeutic target for epilepsy, pain management, and neurodegenerative disorders.
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Metabotropic Glutamate Receptor 8 (GRM8) Antibody
GRM8 Antibody is a Rabbit Polyclonal antibody against GRM8. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Metabotropic Glutamate Receptor 8 (GRM8) Antibody
GRM8 Antibody is a Rabbit Polyclonal against GRM8.
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GRM8 Antibody is a Rabbit Polyclonal against GRM8.
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