Human Metabotropic glutamate receptor 4 (GRM4) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Metabotropic glutamate receptor 4 (GRM4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Metabotropic glutamate receptor 4 (GRM4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Metabotropic glutamate receptor 4 (GRM4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q14833 |
| Gene ID | 2914 |
| OMIM | 604100 |
| Alias | GRM4,GPRC1D,MGLUR4,mGlu4 |
| Background | Elisa kits for GRM4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GRM4, or mGluR4, belongs to the Group III metabotropic glutamate receptors and primarily couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cyclic AMP (cAMP) levels. GRM4 is predominantly expressed in the cerebellum, basal ganglia, and thalamus, where it functions as a presynaptic receptor to suppress excessive glutamate release. It plays a critical role in regulating synaptic plasticity, motor coordination, and neuronal excitability. GRM4 activation has neuroprotective effects, reducing excitotoxicity and inflammation in neurological conditions. Dysregulation of GRM4 has been associated with Parkinson’s disease, anxiety, and chronic pain, where impaired glutamate signaling contributes to disease pathology. GRM4 agonists are being investigated as therapeutic agents for Parkinson’s disease, as they modulate basal ganglia circuitry and improve motor symptoms. Additionally, GRM4’s role in neuroprotection and reducing inflammation makes it a promising target for treating neurodegenerative diseases, chronic pain, and psychiatric disorders.
Related Products
anti- GRM4 antibody
Ver Producto
Glutamate Metabotropic Receptor 4 (GRM4) Antibody
GRM4 Antibody is a Rabbit Polyclonal antibody against GRM4. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
Ver Producto
Metabotropic Glutamate Receptor 4 (GRM4) Antibody
Metabotropic Glutamate Receptor 4 (GRM4) Antibody is a Rabbit Polyclonal antibody for the detection of GRM4.
Ver Producto