Human Metabotropic glutamate receptor 3 (GRM3) ELISA Kit
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Description
Human Metabotropic glutamate receptor 3 (GRM3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Metabotropic glutamate receptor 3 (GRM3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Metabotropic glutamate receptor 3 (GRM3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q14832 |
| Gene ID | 2913 |
| OMIM | 601115 |
| Alias | GRM3,GLUR3,mGlu, GPRC1C,MGLUR3,mGluR3,glutamate receptor |
| Background | Elisa kits for GRM3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GRM3, also known as mGluR3, is a Group II metabotropic glutamate receptor that couples to Gi/o proteins, leading to the inhibition of adenylate cyclase and reduced cAMP production. GRM3 is expressed in glial cells and neurons, where it modulates synaptic transmission, glutamate release, and neuroinflammation. GRM3 plays an important role in maintaining synaptic plasticity and protecting against excitotoxicity by regulating extracellular glutamate levels. Dysregulation of GRM3 has been linked to psychiatric disorders, including schizophrenia, where genetic variations in the GRM3 gene are associated with cognitive deficits and impaired glutamatergic signaling. GRM3 is also involved in neuroprotection, reducing oxidative stress and inflammation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. GRM3 agonists are being explored as therapeutic agents for schizophrenia, neuroinflammation, and cognitive impairment, as they stabilize glutamate levels and improve neuronal function. Its role in glutamate homeostasis highlights its therapeutic potential in CNS disorders.
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