Glutamate Receptor, Metabotropic 3 (GRM3) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
GRM3 Antibody is a Rabbit Polyclonal antibody against GRM3. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glutamate Receptor, Metabotropic 3 (GRM3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14832 |
| Gene ID | 2913 |
| NCBI Accession | NP_000831.2 |
| Alias | GRM3,GLUR3,mGlu, GPRC1C,MGLUR3,mGluR3,glutamate receptor |
| Background | Antibody anti-GRM3 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
GRM3, also known as mGluR3, is a Group II metabotropic glutamate receptor that couples to Gi/o proteins, leading to the inhibition of adenylate cyclase and reduced cAMP production. GRM3 is expressed in glial cells and neurons, where it modulates synaptic transmission, glutamate release, and neuroinflammation. GRM3 plays an important role in maintaining synaptic plasticity and protecting against excitotoxicity by regulating extracellular glutamate levels. Dysregulation of GRM3 has been linked to psychiatric disorders, including schizophrenia, where genetic variations in the GRM3 gene are associated with cognitive deficits and impaired glutamatergic signaling. GRM3 is also involved in neuroprotection, reducing oxidative stress and inflammation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. GRM3 agonists are being explored as therapeutic agents for schizophrenia, neuroinflammation, and cognitive impairment, as they stabilize glutamate levels and improve neuronal function. Its role in glutamate homeostasis highlights its therapeutic potential in CNS disorders.
Related Products
Glutamate Receptor, Metabotropic 3 (GRM3) Antibody
GRM3 Antibody is a Rabbit Polyclonal antibody against GRM3. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Ver Producto
Metabotropic Glutamate Receptor 3 Antibody
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 (also known as GPRC1C) while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM3 is mediated by a G-protein that inhibits adenylate cyclase activity.
Ver Producto
Glutamate Receptor, Metabotropic 3 (GRM3) Antibody
Glutamate Receptor, Metabotropic 3 Antibody is a Rabbit Polyclonal against Glutamate Receptor, Metabotropic 3.
Ver Producto