Human Melanoma-Derived Growth Regulatory Protein (MIA) Protein
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935106861
info@markelab.com
Precio
2821€ (1 mg)
Protein MIA
proveedor
Abbexareference
abx655766Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Melanoma-Derived Growth Regulatory Protein (MIA) Protein (Active) is an Active Recombinant Human protein.
Background
MIA, also known as Melanoma Inhibitory Activity, is a small secreted protein primarily expressed in melanocytes and chondrocytes, where it regulates cell adhesion, migration, and tumor progression It acts by disrupting the interaction between integrins and the extracellular matrix, facilitating detachment and migration of tumor cells MIA is highly expressed in malignant melanoma and is used as a biomarker for disease progression, metastasis, and treatment monitoring Elevated MIA levels are also observed in other cancers, such as chondrosarcoma and hepatocellular carcinoma, where it contributes to tumor invasiveness Its role extends to cartilage homeostasis and chondrocyte differentiation, implicating MIA in cartilage-related disorders like osteoarthritis Targeting MIA holds therapeutic potential in inhibiting tumor cell dissemination and cartilage degeneration
Características del producto
category
Proteins and Peptides
origin
Human
immunogen target
Melanoma-Derived Growth Regulatory Protein (MIA)
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
MIA
dry ice
No
availability
Shipped within 1-2 months.
alias
Melanoma inhibitory activity protein,MIA1,CD-RAP
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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