Human Melanoma-Derived Growth Regulatory Protein (MIA) Protein
234€ (5 µg)
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935106861
info@markelab.com
name
Human Melanoma-Derived Growth Regulatory Protein (MIA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx260772
tested applications
SDS-PAGE
Description
Melanoma Inhibitory Activity Protein, His Tag Protein is a recombinant cytokine.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | MIA |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Tag: His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | Q16674 |
| Alias | Melanoma inhibitory activity protein,MIA1,CD-RAP |
| Background | Protein MIA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
MIA, also known as Melanoma Inhibitory Activity, is a small secreted protein primarily expressed in melanocytes and chondrocytes, where it regulates cell adhesion, migration, and tumor progression It acts by disrupting the interaction between integrins and the extracellular matrix, facilitating detachment and migration of tumor cells MIA is highly expressed in malignant melanoma and is used as a biomarker for disease progression, metastasis, and treatment monitoring Elevated MIA levels are also observed in other cancers, such as chondrosarcoma and hepatocellular carcinoma, where it contributes to tumor invasiveness Its role extends to cartilage homeostasis and chondrocyte differentiation, implicating MIA in cartilage-related disorders like osteoarthritis Targeting MIA holds therapeutic potential in inhibiting tumor cell dissemination and cartilage degeneration
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