Human Macrophage Scavenger Receptor Types I And II (MSR1) Protein

Este producto es parte de MSR1 - macrophage scavenger receptor 1
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546€ (100 µg)

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935106861
info@markelab.com
name
Human Macrophage Scavenger Receptor Types I And II (MSR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx620364
tested applications
ELISA, WB, SDS-PAGE

Description

Human Macrophage Scavenger Receptor Types I And II (MSR1) Protein is a recombinant Human protein produced in a Mammalian cell expression system.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Macrophage Scavenger Receptor Types I And II (MSR1)
Host
Mammalian cells
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 43.96 kDa
Sequence Fragment: Lys77-Leu451
Tag: C-terminal His tag
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
100 µg
Size 2
1 mg
Form
Liquid 
Tested Applications
ELISA, WB, SDS-PAGE
Buffer
0.01 M PBS, pH 7.4.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C for long-term storage. Avoid repeated freeze-thaw cycles.
Dry Ice
No
UniProt ID
P21757
Alias
Macrophage scavenger receptor types I and II,SRA,SR-A,CD204,SR-AI,phSR1,phSR2,SCARA1,SR-AII,SR-AIII,Macrophage acetylated LDL receptor I and II,Scavenger receptor class A member 1
Background
Protein MSR1
Note
This product is for research use only. This product is shipped with ice packs.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

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MSR1 Antibody is a Rabbit Polyclonal antibody against MSR1. This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008].

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