Human Lysosomal Associated Membrane Protein 3 (LAMP3) Protein

Este producto es parte de LAMP- Lysosomal Associated Membrane Protein
Human Lysosomal Associated Membrane Protein 3 (LAMP3) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein LAMP3

proveedor

Abbexa

reference

abx168716

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human LAMP3 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Lysosome-associated membrane glycoprotein 3 (LAMP3), also known as DC-LAMP, is a lysosomal membrane protein predominantly expressed in dendritic cells and other immune cells, where it plays a critical role in antigen processing and presentation LAMP3 expression increases during dendritic cell maturation, facilitating the regulation of lysosomal function and endosomal trafficking It is also involved in lysosome-mediated autophagy and immune responses by regulating cellular degradation pathways Dysregulation of LAMP3 has been linked to cancer progression and metastasis, particularly in breast, cervical, and lung cancers, where its overexpression promotes tumor cell survival and invasion through altered lysosomal activity Additionally, LAMP3 has been implicated in hypoxia response pathways, contributing to cellular adaptation to low oxygen environments Emerging studies highlight its role in viral infections, where it can affect viral replication and host immune response, making LAMP3 a potential biomarker for immune regulation and cancer prognosis

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Lysosomal Associated Membrane Protein 3 (LAMP3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 21.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser222-Thr381 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

LAMP3


dry ice

No


availability

Shipped within 5-7 working days.


alias

CD208,DC LAMP,DC-LAMP,DCLAMP,LAMP,LAMP-3,TSC403,DC-lysosome-associated membrane glycoprotein


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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