Human Lysosomal Associated Membrane Protein 3 (LAMP3) Protein
221€ (10 µg)
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935106861
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name
Human Lysosomal Associated Membrane Protein 3 (LAMP3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168716
tested applications
WB, SDS-PAGE
Description
Human LAMP3 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Lysosomal Associated Membrane Protein 3 (LAMP3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 21.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser222-Thr381 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UQV4 |
| Alias | CD208,DC LAMP,DC-LAMP,DCLAMP,LAMP,LAMP-3,TSC403,DC-lysosome-associated membrane glycoprotein |
| Background | Protein LAMP3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Lysosome-associated membrane glycoprotein 3 (LAMP3), also known as DC-LAMP, is a lysosomal membrane protein predominantly expressed in dendritic cells and other immune cells, where it plays a critical role in antigen processing and presentation LAMP3 expression increases during dendritic cell maturation, facilitating the regulation of lysosomal function and endosomal trafficking It is also involved in lysosome-mediated autophagy and immune responses by regulating cellular degradation pathways Dysregulation of LAMP3 has been linked to cancer progression and metastasis, particularly in breast, cervical, and lung cancers, where its overexpression promotes tumor cell survival and invasion through altered lysosomal activity Additionally, LAMP3 has been implicated in hypoxia response pathways, contributing to cellular adaptation to low oxygen environments Emerging studies highlight its role in viral infections, where it can affect viral replication and host immune response, making LAMP3 a potential biomarker for immune regulation and cancer prognosis
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Lysosomal Associated Membrane Protein 3 (LAMP3) Antibody
LAMP3 Antibody is a Rabbit Polyclonal antibody against LAMP3. Lysosome-associated membrane glycoprotein 3 is a protein that in humans is encoded by the LAMP3 gene. LAMP3 has also recently been designated CD208. Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses.May play a role in dendritic cell function and in adaptive immunity.
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