Human Lysophosphatidic Acid Receptor 1 (LPAR1) Protein

1872€ (1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Lysophosphatidic Acid Receptor 1 (LPAR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654221
tested applications
WB, SDS-PAGE
Description
Human Lysophosphatidic Acid Receptor 1 (LPAR1) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Lysophosphatidic Acid Receptor 1 (LPAR1) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 1 mg |
Size 2 | 5 mg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 1-2 months. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | LPAR1,EDG2,LPA1,VZG1,edg-2,vzg-1,Gpcr26,Mrec1.3,rec.1.3,GPR26,endothelial differentiation gene 2,lysophosphatidic acid G-protein-coupled receptor, 2,LPA receptor 1,lysophosphatidic acid receptor Edg-2 |
Background | Protein LPAR1 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
LPAR1 is a G protein-coupled receptor activated by lysophosphatidic acid (LPA), a bioactive phospholipid involved in diverse cellular processes. LPAR1 is widely expressed in various tissues, including the brain, lungs, and fibroblasts, where it mediates cell proliferation, survival, migration, and cytoskeletal reorganization. LPAR1 couples to multiple G proteins (Gi, Gq, and G12/13), activating pathways such as MAPK, Rho/ROCK, and PI3K/Akt. In fibrosis, LPAR1 signaling promotes fibroblast activation and extracellular matrix deposition, contributing to pulmonary, hepatic, and renal fibrosis. It is also implicated in neuropathic pain, where LPAR1 activation sensitizes pain pathways and amplifies neuronal signaling. In cancer, LPAR1 drives tumor growth, metastasis, and angiogenesis, particularly in breast and lung cancers. Dysregulation of LPAR1 is associated with inflammatory disorders, cancer progression, and fibrosis. LPAR1 antagonists are being developed as potential therapies for fibrotic diseases, neuropathic pain, and cancer, highlighting its role as a key modulator of cell migration and tissue remodeling.
Related Products

Human LPAR1 (Lysophosphatidic acid receptor 1) ELISA Kit
Ver Producto
LPA Receptor 1 Antibody
LPA Receptor 1 Antibody is a Rabbit Polyclonal antibody against Mouse.
Ver Producto
Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit
Human Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LPAR1 concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Lysophosphatidic Acid Receptor 1 (LPAR1)
Ver Producto