Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit

Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for BRCC3

proveedor

Abbexa

reference

abx050248

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) concentrations in tissue homogenates, cell lysates and other biological fluids. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Características del producto

category

ELISA Kits


immunogen target

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

BRCC3


dry ice

No


NCBI accession

NP_001018065.1, NM_001018055.2, NP_001229569.1, NM_001242640.1, NP_077308.1, NM_024332.3


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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