Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit

Descripción

Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) concentrations in tissue homogenates, cell lysates and other biological fluids. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Características del producto

immunogen target

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3)

reactivity

Human

test range

0.156 ng/ml - 10 ng/ml

assay data

Quantitative

detection method

Colorimetric

sample type

Tissue homogenates,Cell lysates,Other biological fluids

size 1

96 tests

storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit

or code

BRCC3

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/P46736

gene id

https://www.ncbi.nlm.nih.gov/gene/79184

NCBI accession

NP_001018065.1, NM_001018055.2, NP_001229569.1, NM_001242640.1, NP_077308.1, NM_024332.3

note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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proveedor

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reference

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Tested Applications

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reactivity

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status

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clonality

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Precio a consultar

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody

proveedor

Abbexa

reference

abx007111

Tested Applications

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

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175€ (20 µl)