Human LPAR1(Lysophosphatidic acid receptor 1) ELISA Kit
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name
Human LPAR1(Lysophosphatidic acid receptor 1) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH2508
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.313-20ng/ml |
| Size 1 | 96T |
| Sample Type | Serum,Plasma,Tissue homogenates,Other biological fluids |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 6 months |
| UniProt ID | Q92633 |
| Alias | LPAR1,EDG2,LPA1,VZG1,edg-2,vzg-1,Gpcr26,Mrec1.3,rec.1.3,GPR26,endothelial differentiation gene 2,lysophosphatidic acid G-protein-coupled receptor, 2,LPA receptor 1,lysophosphatidic acid receptor Edg-2 |
| Background | Elisa Kits LPAR1 |
| Status | RUO |
LPAR1 is a G protein-coupled receptor activated by lysophosphatidic acid (LPA), a bioactive phospholipid involved in diverse cellular processes. LPAR1 is widely expressed in various tissues, including the brain, lungs, and fibroblasts, where it mediates cell proliferation, survival, migration, and cytoskeletal reorganization. LPAR1 couples to multiple G proteins (Gi, Gq, and G12/13), activating pathways such as MAPK, Rho/ROCK, and PI3K/Akt. In fibrosis, LPAR1 signaling promotes fibroblast activation and extracellular matrix deposition, contributing to pulmonary, hepatic, and renal fibrosis. It is also implicated in neuropathic pain, where LPAR1 activation sensitizes pain pathways and amplifies neuronal signaling. In cancer, LPAR1 drives tumor growth, metastasis, and angiogenesis, particularly in breast and lung cancers. Dysregulation of LPAR1 is associated with inflammatory disorders, cancer progression, and fibrosis. LPAR1 antagonists are being developed as potential therapies for fibrotic diseases, neuropathic pain, and cancer, highlighting its role as a key modulator of cell migration and tissue remodeling.
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